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Title: Epidemiology of osteoarthritis: an update
Author(s): Sharma L, Kapoor D, Issa S
Source: CURRENT OPINION IN RHEUMATOLOGY 18 (2): 147-156 MAR 2006
Document Type: Review
Language: English
Cited References: 89      Times Cited: 15
Abstract: Purpose of review As the most common arthritis and a leading cause of chronic disability, osteoarthritis is associated with substantial cost to the individual and to society. Epidemiologic studies have supplied, in addition to incidence, prevalence and risk factor data, much of what is known about the natural history of osteoarthritis.

Recent findings Especially given the anticipated increase in osteoarthritis prevalence, the need to identify risk factors for incident osteoarthritis, osteoarthritis progression, osteoarthritis-associated physical function decline, and disability is a high priority. As this review illustrates, the emphasis has shifted in osteoarthritis epidemiology towards the identification of risk factors for osteoarthritis progression rather than incidence.

Summary Several risk factors for progression are emerging, many of which are impairments or pathology in the local joint organ environment. This shift in focus relates in part to the concept that local risk factors might ultimately be targeted to delay osteoarthritis progression or to enhance the effect of a disease-modifying drug.

Addresses: Sharma L (reprint author), Northwestern Univ, Feinberg Sch Med, Div Rheumatol, 240 E Huron St,McGaw M-300, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Div Rheumatol, Chicago, IL 60611 USA
Subject Category: Rheumatology
IDS Number: 035KS
ISSN: 1040-8711