If you are seeing this message, you may be experiencing temporary network problems. Please wait a few minutes and refresh the page. If the problem persists, you may wish to report it to your local Network Manager.

It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to help minimise these problems.

Cover Image

Arthritis & Rheumatism

RSS feed for Arthritis & Rheumatism What is RSS?

Volume 54, Issue 12 , Pages 3842 - 3849

Published Online: 28 Nov 2006

Copyright © 2006 by the American College of Rheumatology

Journal Homepage Link
E-Mail and Print ToolbarE-MailPrint

Published on behalf of
American College of Rheumatology
Go to Society Site

 Research Article
Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis
Laura E. Thorp, D. Richman Sumner, Joel A. Block, Kirsten C. Moisio, Susan Shott, Markus A. Wimmer *
Rush University Medical Center, Chicago, Illinois
email: Markus A. Wimmer (markus_a_wimmer@rush.edu)

*Correspondence to Markus A. Wimmer, Department of Orthopedic Surgery, Tribology Section, Rush University Medical Center, Amour Academic Facilities, Suite 761, 1653 West Congress Parkway, Chicago, IL 60612

Dr. Sumner received honoraria (less than $10,000) for participation in a 1995 Smith & Nephew workshop on osteoarthritis.

Funded by:
 NIH; Grant Number: SCOR 1P50-AR-048941
 Promotion of Doctoral Studies grant from the Foundation for Physical Therapy


To compare the knee joint loading patterns in individuals with differing radiographic grades of knee osteoarthritis (OA) for characterization of the mechanical implications of different structural states, and to compare the knee adduction angular impulse, a measure of gait complementary to the commonly used peak knee adduction moment.

Asymptomatic subjects (those without knee OA) having a Kellgren/Lawrence (K/L) radiographic severity grade of 0 or 1 (n = 28) and subjects with symptomatic knee OA having K/L grades of 2 (n = 66) or 3 (n = 23) were recruited. Gait analysis was used to calculate the peak external knee adduction moment and the external knee adduction angular impulse for the whole stance and for the 4 subdivisions of stance.

Both the peak knee adduction moment and the knee adduction angular impulse increased with K/L radiographic grade (P < 0.05). However, only the knee adduction angular impulse differed between subjects with moderate (grade 3) and those with mild (grade 2) radiographic knee OA (P < 0.05).

The differences between mild and moderate symptomatic radiographic knee OA are not only structural but also functional, based on the magnitude of load in the medial knee joint. Moreover, knee adduction angular impulse provides additional information beyond that available from the peak knee adduction moment, and may therefore be an important gait parameter to include in OA research. These findings are important for our understanding of the pathophysiologic mechanisms of OA.

Received: 1 December 2005; Accepted: 24 August 2006

Digital Object Identifier (DOI)

10.1002/art.22247  About DOI

Related Articles

  • Find other articles like this in Wiley InterScience
  • Find articles in Wiley InterScience written by any of the authors

Wiley InterScience is a member of CrossRef.

Cross Ref Memeber

Search For Articles In This Title

Arthritis & Rheumatism

Search By Citation

Sign Up Now
Wiley InterScience MobileEdition

Get select content from some of Wiley's leading publications delivered to your PDA — free!

Sign up now

Reprint Inquiries
Wiley InterScience Article Reprints
Need a reprint?

Paper or electronic reprints are available for all content published on Wiley InterScience. Inquiries can be submitted online.

Find out more about reprints

Now Available
General Medicine

 Wiley InterScience Backfile Collections

Fully searchable and live-linked with current web content, this backfile brings the complete contents of 20 leading journals, 62,500 articles, to your desktop. A one-time fee delivers ongoing access.

Find out more
Request a Quote

Essential Evidence Plus

all-the-time answers
at the point of care.

Subscribe Today!

Now Available
Backfiles on Pay-Per-View

 Wiley InterScience Backfile Collections

More than 600,000 journal articles starting at Volume 1, Issue 1, dating as far back as 1800s and spanning the disciplines of chemistry, life sciences, medicine and materials science are now available online for Pay-Per-View purchase on Wiley InterScience.

Browse Journals by Subject

EBM Guidelines

EBM Guidelines

(Evidence-Based Medicine)

The key source of practical information for primary care with the most extensive collection of concise treatment recommendations


Also of Interest

Musculoskeletal Care journals

Wiley publishes a full range of Musculoskeletal Care journals