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Published Online: 28 Nov 2006
Copyright © 2006 by the American College of Rheumatology
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Research ArticleKnee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis | Laura E. Thorp, D. Richman Sumner , Joel A. Block, Kirsten C. Moisio, Susan Shott, Markus A. Wimmer * | Rush University Medical Center, Chicago, Illinois
| | email: Markus A. Wimmer (markus_a_wimmer@rush.edu) |
*Correspondence to Markus A. Wimmer, Department of Orthopedic Surgery, Tribology Section, Rush University Medical Center, Amour Academic Facilities, Suite 761, 1653 West Congress Parkway, Chicago, IL 60612 Dr. Sumner received honoraria (less than $10,000) for participation in a 1995 Smith & Nephew workshop on osteoarthritis. Funded by:
 NIH; Grant Number: SCOR 1P50-AR-048941
Promotion of Doctoral Studies grant from the Foundation for Physical Therapy
Objective | | To compare the knee joint loading patterns in individuals with differing radiographic grades of knee osteoarthritis (OA) for characterization of the mechanical implications of different structural states, and to compare the knee adduction angular impulse, a measure of gait complementary to the commonly used peak knee adduction moment. |
Methods | | Asymptomatic subjects (those without knee OA) having a Kellgren/Lawrence (K/L) radiographic severity grade of 0 or 1 (n = 28) and subjects with symptomatic knee OA having K/L grades of 2 (n = 66) or 3 (n = 23) were recruited. Gait analysis was used to calculate the peak external knee adduction moment and the external knee adduction angular impulse for the whole stance and for the 4 subdivisions of stance. |
Results | | Both the peak knee adduction moment and the knee adduction angular impulse increased with K/L radiographic grade (P < 0.05). However, only the knee adduction angular impulse differed between subjects with moderate (grade 3) and those with mild (grade 2) radiographic knee OA (P < 0.05). |
Conclusion | | The differences between mild and moderate symptomatic radiographic knee OA are not only structural but also functional, based on the magnitude of load in the medial knee joint. Moreover, knee adduction angular impulse provides additional information beyond that available from the peak knee adduction moment, and may therefore be an important gait parameter to include in OA research. These findings are important for our understanding of the pathophysiologic mechanisms of OA. |
Received: 1 December 2005; Accepted: 24 August 2006 10.1002/art.22247 About DOI
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